泮托拉唑防治危重症患者消化道出血80例临床观察

Clinical Observation of Pantoprazole on the Prevention and Treatment of 80 ICU Cases of Digestive Hemorrhage

目的探讨应用泮托拉唑对ICU危重症患者消化道出血的预防和治疗作用,观察其疗效。方法将入住ICU的128例危重症患者随机分为A、B两组。A组应用泮托拉唑;B组给予法莫替丁。观察两组消化道出血的发生率。结果A组80例,显效74例(92.5%),有效6例(7.5%),总有效率为100%。B组48例,显效26例(54.2%),有效16例(33%),无效6例(12.5%),总有效率为87%。两组比较有显著性差异(P<0.01)。结论危重症患者早期应用泮托拉唑,可显著降低消化道出血的发生率,降低了死亡率。

Objective To probe into the applieation of pantoprazole for the prevention and treatment of digestive hemorrhage in ICU patients and observe its efficacy. Methods 128 ICU patients were randomly divided into A and B groups. Pantoprazole was administered in A group and famolidine was in B group. The incidence of digestive hemorrhage was observed in two groups. Results Of 80 eases in A group,74 cases （92.5%） were effective markedly,6 eases （7.5%） were effective and the total effective rate was 100%. Of 48 cases in B group,26 cases （54.2%） were effective markedly, 16 cases （33%） were effective,6 cases （ 12.5% ） were failed and the total effective rate was 87%. The significant difference presented in comparison of two groups （P 〈0. 01 ）. Conclusion The application of pantoprazole in ICU patients at early stage can reduce the incidence of digestive hemorrhage and mortality significantly.