MMP-9、Survivin、COX-2在胃癌组织中的表达及相关性

Objective to Explore the Expression and Their Relationship with MMP-9、Survivin and COX-2 in Gastric Carcinoma

目的探讨胃癌组织中基质金属蛋白酶-9（MMP-9）、凋亡抑制蛋白（Survivin）、环氧合酶-2（COX-2）的表达及其相关性。方法采用免疫组化S-P法,分别检测58例人胃癌手术标本及正常胃黏膜中MMP-9、Survivin、COX-2的阳性率。结果在胃癌组织中MMP-9、Survivin、COX-2阳性率分别为68.9%、79.31%、82.76%,均高于正常胃粘膜（P〈0.01）。MMP-9、Survivin、COX-2的表达与胃癌的浸润深度、淋巴结转移及TNM分期有关（P〈0.05）,而与胃癌的性别、年龄、部位及大小无相关性（P＆gt;0.05）,MMP-9又与胃癌分化程度相关（P〈0.05）。三者在胃癌中表达有相关性（P〈0.05）。结论MMP-9、Survivin、COX-2共同促进肿瘤的发生、侵袭和转移,可作为反映胃癌生物学行为的指标。

Methods The positive rate of MMP-9、Survivi、COX-2 in the tumor tissues from 58 cases of gastric carcer was examined by immunohistochemical S-P method and the positive rate of MMP-9、COX-2 in the normal gastric mucosa. Results The positive rate of MMP-9、 Survivi、COX-2 in gastric carcer tissues was 82.76%,68.9%,higher than those of the normal stomach mucous （P0.01）.The expression of MMP-9、Survivi、COX-2 was correlated with the depth of gastric cancer metastasis（P0.05）、lymph node transference （P0.05） and TNM stage （P0.01）,but was not associated with sex、age、location and size of gastric cancer （P0.05）,MMP-9 was associated with the degree of differentiation of gastric cancer （P0.05）.The expression of MMP-9、Survivi、COX-2 has correlation in gastric cancer tissues. Conclusion MMP-9、Survivi、COX-2 which promote occurrence、sinvansion and transition of gastric cancer.They are the predictors for the biological behavior of gastric cancer.