卡维地洛治疗充血性心力衰竭的疗效观察

The Effect of Carvedilol in Treatment of Congestive Heart Failure

目的观察卡维地洛对充血性心力衰竭（CHF）的临床疗效。方法将48例CHF患者随机分为治疗组和对照组,对照组24例,给予常规抗心力衰竭治疗（地高辛、利尿剂、ACEI）;治疗组24例,在对照组常规治疗基础上加用卡维地洛,卡维地洛从初始剂量2.5㎎,每日两次开始,根据耐受情况逐渐上调至最大耐受量40㎎/天,疗程3个月。观察治疗前后患者血压、心率、左室收缩末期内径（LVESD）、左室舒张末期内径（LVEDD）、左室射血分数（LVEF）的变化。结果治疗组总有效率（91.7%）明显高于对照组（75%）,差异有显著性（P〈0.05）。两组血压、心率、LVESD、LVEDD及LVEF均较治疗前明显改善（P〈0.05或P〈0.01）,但治疗组较对照组改善更为明显（P〈0.05或P〈0.01）。结论卡维地洛对充血性心力衰竭的治疗有显著效果。

Objective to explore the clinical effect of carvedilol in treatment of congestive heart failure （CHF）. Method 48 CHF patients were divided randomed into two groups： the 24 controls with traditional scheme; and the other 24 cases in treatment group with traditional scheme combined with carvedilol, the dosage and usage of carvedilol was： initiate dosage was 2.5 mg twice a day, and than, increased gradually to 40 mg per day for 3 months. Some parameters were observed before and after treatment： blood pressure, heart rate, LVESD, LVEDD, LVEF. Result it is more effectively in treatment group （91.7%） than control group （75%）, there is significant difference between two groups （P0.05）, all the parameters in two groups include blood pressure, heart rate, LVESD, LVEDD, LVEF were meliorated, （P0.05） or （P0.01）, but the treatment group is more. （P 0.05 or P0.01）. Conclusion carvedilol is effective in treatment of congestive heart failure.