血清绒毛膜促性腺激素、钙、尿酸和肌酐水平与妊高征的关系

Correlations of serum human chorionic gonadotropin,calcium,uric acid,creatinine levels and pregnancy-induced hypertension

目的 探讨孕妇血清绒毛膜促性腺激素（β-HCG）、钙、尿酸和肌酐水平与妊娠高血压综合征（妊高征）的关系。方法采用化学发光法检测血清β-HCG，生化分析法检测血清钙、尿酸、肌酐。结果妊高征患者妊娠中期血清β-HCG明显高于无妊高征妇女；中、晚期妊娠的妊高征患者血清钙明显降低，尿酸和肌酐升高，差异有统计学意义（P〈0．01～0．05）。结论妊娠中期血清β-HCG可预测妊高征的发生，妊娠中、晚期钙下降可能是妊高征的预兆，尿酸和肌酐升高提示肾功能损害。

Objective To investigate the relationships between the maternal serum human chorionic gonadotropin（β-HCG）, calcium, uric acid, creatinine levels and pregnancy induced hypertension（PIH）. Methods Chemiluminescence was adopted to detect β-HCG and biochemical assay was used to measure calcium, uric acid and creatinine. Results Women with PIH had significantly higher β-HCG level than those without PIH;during middle and late pregnancy, serum calcium was significantly lower while uric acid and creatinine increased in women with PIH, and the difference was significant（P 〈0. 01-0. 05）. Conclusion In the second trimester, serum β-HCG can predict the occurrence of PIH. Calcium decline during middle and late pregnancy may be a harbinger of PIH while elevated uric acid and creatinine may indicate the damage of renal function.