前列腺癌血清PSA与磁共振波谱变化的相关性研究

Correlation between Serum PSA and MRS in Patients with Prostate Cancer

目的:探讨前列腺癌患者磁共振波谱(MRS)改变与血清中总前列腺特异抗原(TPSA)、游离前列腺特异抗原(fPSA)及两者比值(f/T)的相关性。方法:30例经活检证实为前列腺癌患者TPSA、fPSA及f/T值为参数,将3组数据分别与前列腺癌兴趣区所得(Cho+Cr)/Cit值的平均数进行相关性分析。结果:CC/C比值与血清总PSA浓度平均值呈正相关关系(相关系数r=0.750),差异具有显著性意义(P<0.01);与血清游离PSA浓度呈正相关关系(相关系数r=0.814),差异具有显著性意义(P<0.05);与f/T值呈正相关关系(相关系数r=0.189),差异无显著性意义(P=0.318>0.05)。结论:CC/C值与血清总PSA浓度及游离PSA浓度呈正相关,而CC/C值较高患者更易于发现和确定前列腺内发生代谢改变的区域,因此PSA值较高患者行MRS更具临床意义。

Objective：To investigate the correlation between the magnetic resonance spectroscopy（MRS） change and the three sets of clinical laboratory data including total prostate-specific antigen（TPSA）,free prostate specific antigen（fPSA） and the ratio between fPSA and TPSA（f/T）.Methods：In 30 cases of prostate cancer confirmed by biopsy,TPSA,fPSA and f/T parameters were determined after MRS examination.The correlation between each set of the clinical laboratory data and the average value of（Cho＋Cr）/Cit obtained in the specific interest areas was analyzed.Results：Using the method of MRI and MRS,30 cases of patients were diagnosed as having prostate cancer,of which 29 cases had MRS changes.The results of statistical studies showed that the correlation between the value of CC/C and the average concentration of serum of total PSA was positive（r=0.750,P〈0.05）;the correlation between CC/C and the concentration of serum free PSA was positive（r=0.814,P〈0.05）;the correlation between the value of CC/C and f/F value was positive（r=0.189,P=0.3180.05）,without statistical significance.Conclusion： It is easier to identify the abnormal metabolic regions in patients with prostate cancer with higher CC/C value,and the clinical value of MRS in patients with higher PSA value is of greater help to clinical management.