乙肝携带孕妇阻断治疗后新生儿乙肝标志物的表达形式及其意义

The model and significance of newborn′s HBVM whose mother is a HBV carrier and has been block treated

目的了解对乙型肝炎携带孕妇进行阻断治疗后新生儿乙肝标志物的模式及其意义。方法对我院近两年分娩的333例乙肝病毒携带孕妇的资料进行回顾性分析,观察新生儿脐带血的乙肝病毒标志物模式及其与母亲模式的关系。结果新生儿HBVM模式一共有17种,新生儿的模式多于孕妇;通过配对观察:新生儿所出现的阳性结果几乎都是其母亲所具有的阳性结果,即胎儿几乎没有自己产生出新的抗体;胎儿HBeAg阳性而可能同时出现HBsAg阴性。结论新生儿体内的抗原抗体几乎来自于母体;孕期采用HBVIG阻断治疗,其新生儿HBsAg阴性不能认为没有被乙肝病毒感染;实际宫内感染率应该高于出生时酶联免疫法的检出率。

Objective To know the model and significance of newborn＇s HBVM whose mother is a HBV cartier and has been block treated. Methods We perform a retrospective study on 333 cases of HBV carried pregnant women in the ninth people＇s hospital of chengdu to observe the relation of the model of HBV marker between pregnant woman and her newborn＇s umbilical cord. Results There are 17 kinds of newborns＇ HBVM models which is more than the mothers＇. By matching compare, we find that almost all the positive results of newborns are from their mothers, which means the fetus can hardly produce any new antibodies by itself. Positive HBeAg and negative HBsAg may exist in fetus at the same time. Conclusion Newborn＇s antigens and antibodies are almost from it＇s mother;We can not confirm the newborn with negative HBsAg is not infected with hepatitis B virus after it＇s mother received HBVIG to interrupt the infection;The exact rate of fetal infection with hepatitis B virus should be higher than which by means of ELISA when born.