1796例泌尿生殖道支原体培养及药敏结果分析

Detection and drug sensitivity assay of Mycoplasma in 1796 cases of genitourinary infection

目的分析新乡地区1796例泌尿生殖道标本的支原体培养及抗生素药物敏感试验,指导临床合理使用抗生素。方法支原体培养鉴定、药敏试剂盒购自贝瑞特公司。同时检测解脲支原体和人型支原体,并进行10种抗生素的药敏试验。数据统计采用2χ检验。结果支原体培养1596例标本中,541例解脲脲原体(Uu)阳性,阳性率为33.9%;39例人型支原体(Mh)阳性,阳性率为2.4%;解脲脲原体、人型支原体均阳性76例,阳性率为4.8%。200例正常对照组27例阳性,阳性率为13.5%。药敏结果显示,强力霉素、克拉霉素和美满霉素的抗菌活性较强。结论支原体感染以Uu为主,Uu+Mh次之,正常人泌尿生殖道支原体阳性率为13.5%。只有某些血清型感染且在达到一定浓度以上同时宿主处于多种病原体感染或免疫机制紊乱时,Uu才能致病。避免滥用抗生素引起生殖道菌群失调。临床上治疗Uu感染、Mh感染或Uu+Mh混合感染时,建议选用强力霉素、克拉霉素和美满霉素。

Objective To analyze the Mycoplama culture was carried out with the samples of 1796 cases and their susceptibility to antibiotics in Xinxiang city,so as to provide evidence forguiding drug use in clinics.Method Mycoplasma culture was used,identification and sensitivity testing reagent box buying self Beiruite company.Detecting Ureaplasma urealyticum（Uu） and Mycoplasma hominis（Mh） at the same time,and their sensitivity to 10 drugs.χ^2 checkouts the data was counted adopt.Result 1596 cases mycoplasma trains,541 cases were（Uu） positive and its positively rate was 33.9%;39 cases（Mh） were positive and its positively rate was 2.4%;The mixed infection 76 cases and its rate was 4.8%.27 of 200 cases were not inflected with mycoplasma,The positive rate was 13.5%.The drug-sensitivity test showed that the doxycycline clathyromycin and minocyclin had preferable antimicrobial activities.Conclusion The most major mycoplasma inflection is Uu,and more mycoplasma inflection is Uu with Mh.The infection rate of mycoplasma was 13.5%.We found pathogenicity of Uu are affected by serotype,density,host,et al.Avoid abuse the antibiotic arouses dysbacteriosis of genitourinary.Mount Mh curing Uu infection,Mh infection or Uu ＋ when blending infection,suggest selecting and using doxycycline,clathyomycin and minocyclin clinically.