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缺氧诱导因子-1α和Ki-67在子宫内膜癌组织中的表达及其生物学行为 被引量：4

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摘要 目的:探讨缺氧诱导因子(HIF)-1α和Ki-67在子宫内膜癌生长转移中的作用。方法:免疫组化法检测子宫内膜癌组织中HIF-1α和Ki-67的表达,分析HIF-1α和Ki-67与临床病理特征之间的关系。结果:子宫内膜癌组织中HIF-1α和Ki-67阳性表达率显著高于正常子宫内膜组织。HIF-1 o和Ki-67表达均与有无淋巴结转移、病理分级及临床分期有关,与肿瘤的病理组织类型无关。HIF-1 α与Ki-67表达呈正相关(=0.426,P<0.01)。结论:HIF-1α和Ki-67过度表达可能与子宫内膜癌的生长转移有密切关系。
作者 李晓玲 李晓兰 邓亚丽 谢艳霞
机构地区 湘南学院临床系妇科教研室 湘南学院附属医院病理科
出处 《实用医学杂志》 CAS 北大核心 2009年第24期4111-4113,共3页 The Journal of Practical Medicine
基金 2008年度湖南省教育厅研究项目(编号:08C812)
关键词 子宫内膜肿瘤 缺氧诱导因子1 Α亚基 KI-67抗原
分类号 R737.33 [医药卫生—肿瘤]
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参考文献9

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共引文献7

同被引文献41

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二级引证文献11

实用医学杂志
2009年 第24期

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