1-磷酸鞘氨醇在气道功能和疾病中的作用
摘要
鞘磷脂是细胞膜脂双层的主要结构成分,鞘磷脂的代谢产物包括:神经酰胺、鞘氨醇和1-磷酸鞘氨醇(S1P)等,它们在细胞牛长、存活和凋亡中起重要作用。SIP存人体血浆中与白蛋白和脂蛋白(尤其是高密度脂蛋白)紧密相连,其生理浓度是0.2—0.9μmol/L.在血清中的浓度是0.4~1.1μmol/L^[1-2]。它是由鞘氨醇通过鞘氨醇激酶(SPHK)磷酸化而形成的,巨噬细胞、肥大细胞、树状细胞和血小板等均可产牛.
出处
《实用医学杂志》
CAS
北大核心
2009年第24期4253-4254,共2页
The Journal of Practical Medicine
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