响应面法优化中药片剂薄膜包衣工艺研究

Study on the Optimization of Film Coating Technology of Chinese Patent Tablet With Response Surface Method

目的:采用响应面法优化中药片剂薄膜包衣的工艺条件。方法:用多孔眼高效包衣机进行实验性薄膜包衣。结果:控制包衣液浓度为16.3%,中药素片含水量为4.5%-5%,硬度为5.5-6kg/mm2;在此条件下,包衣合格率为98.3%。结论:此法适用于多孔眼高效包衣机。

Objective： To optimize the technologic conditions of film coating of Chinese patent tablet with response surface method. Methods： Majority grommet efficient coating machine was used to maka experimental fihn coating. Results： coating solution was 16.3%, moisture capacity of Chinese patent naked table was 4.5%-5%, calcium hardness was 5.5-6 kg/mm2. at the condition, the conformity rate of coating was 98.3%. Conclusion： The method is fit for Majority grommet efficient coating machine.