葛根素注射液在家兔体内的药动学研究

Study on pharmacokinetics of puerarin injection in rabbits

[目的]研究葛根素注射液在家兔体内的药动学规律。[方法]家兔耳缘静脉注射葛根素注射液后,采用高效液相色谱法测定血浆中葛根素的含量。[结果]葛根素的血药浓度-时间曲线符合三室开放模型,其主要药动学参数分别为消除相半衰期(t1/2β)=1.33h,血药浓度-时间曲线下面积(AUC)=13.0(mg/L).h,消除率[CL(S)]=6.16mg/kg/h(/mg·L)。[结论]明确了葛根素在家兔体内的药动学特征。

[Objective] To observe the pharmacokinetic characteristics of Puerarin injection in rabbits. [Methods] After giving of injection of Puerarin i.v. into rabbits,HPLC was used to determine the puer-arin levels in the biological samples. [Results] The plasma concentration-time course of puerarin fitted well to one-compartment model and with the following pharmacokinetic parameters：Ke=0.02min-1,t1/ 2ke=35.66min,AUC=495.27（mg/kg）omin.[Conclusion] The pharmacokinetic characteristics of puerarin in rabbits was understood.