脑梗塞的听觉事件相关电位P300初步研究

A preliminary study of auditory event related potential P300 in cerebral infarction

目的分析脑梗塞患者与正常老人的听觉事件相关电位P300构成的特点。方法使用J-1ERP仪器和听觉oddball范式,记录了31例脑梗塞患者和40例正常老人在Oz、Cz、Pz新组合三个记录点上P300,并分析其P3亚成份。结果P3是一个复合波,对照组波形分化好,P3a、P3b双峰明显,稳定。在Oz、Cz、Pz点双峰波出现率分别为42.5%、55.0%和52.5%。在Pz点,脑梗塞组P3双峰波出现率低于对照组,有统计学差异(χ2=8.14,P=0.004)。在Oz点P3a潜伏期,P3a、P3b波幅上,脑梗塞组表现为同一趋势,即潜伏期延迟和波幅低于对照组,有统计学差异。结论P300对判断脑梗塞患者的认知状况有一定临床价值。

Objective： To analyze the characteristics of subcomponents of auditory event related potential P300 in patients with cerebral infarction （CI）. Methods： The auditory P300 was recorded at Oz,Cz and Pz of the scalp in 31 CI patients and 40 normal controls （NC）. The subeomponents P3a and P3b of P300 were analyzed. Results： The incidence of P3a - P3b of NC group was 42.5 % （Oz） , 55.0% （Cz） and 52.5 % （Pz）. CI group presented a lower incidence of P3a -P3b at Pz （χ^2 = 8.14 ,P = 0.004）. Compared with the NC group, CI group presented prolonged Oz latencies, and decreased Oz amplitudes. Conclusion：P300 potentials can reflect the cognition in CI, which has remarkable clinical value in making reasonable treatment plan.