妊娠高血压疾病患者血、尿瘦素水平的测定及临床意义分析

Detection of Serum and Urinary Leptin Levels in Hypertensive Disorder Complicating Pregnancy and its Clinical Parameters Analysis

[目的]检测妊娠高血压疾病患者血、尿瘦素水平,探讨其临床意义。[方法]采用ELISA法测定40例妊娠高血压疾病和50例正常孕妇血、尿瘦素水平,结合BMI指数、尿蛋白、收缩压和舒张压等相关指标分析其临床意义。[结果]妊娠高血压疾病组血、尿瘦素水平均高于正常妊娠对照组(P<0.05);妊娠高血压疾病组中妊娠高血压患者血瘦素水平与对照组无差异,轻度子痫前期、重度子痫前期患者血瘦素水平明显高于正常对照组(P<0.05);妊娠高血压、轻度子痫前期患者尿瘦素水平与对照组之间无差异,但均明显低于重度子痫前期患者尿瘦素水平(P<0.05);血瘦素水平与患者的收缩压、舒张压相关,尿瘦素水平与妊娠高血压疾病患者的尿蛋白量相关。[结论]妊娠期血瘦素水平升高与妊娠高血压疾病的发生有关,尿瘦素水平增高与肾功能受损有关。

[ Objective]To investigate the changes and the association of serum and urinary leptin levels in patients with hyperten- sive disorder complicating pregnancy and its clinical parameters analysis. [ Methods]Serum and urinary leptin levels were detected by ELISA in 40 patients with hypertensive disorder complicating pregnancy and 50 normal pregnancy women, and the clinic parameters analysis was made into body mass index （MBI）, urinary proteins, systolic pressure, and diastolic pressure and so on. [Results]The levels of serum and urinary leptin in patients with hypertensive disorder complicating pregnancy were both higher than those compared with the normal pregnancy women（ P 〈 0.05）. No significant difference between gestational hyperrnsion and normal pregnant wom- en in serum leptin levels. However, the levels of serum and urinary leptin of mild pre-eclampsia and severe pre-eclampsia patients were both higher than those in normal pregnancy women （ P 〈 0.05）. Although the levels of urinary leptin showed no significant difference during gestational hypertension patients, mild pre-eclampsia patients and normal pregnancy women, the levels of urinary leptln in these three sorts of pregnant women were significantly lower than those in severe pre-eclampsia patients（ P 〈 0.05 ）. The levels of serum leptin were changed with the levels of systolic pressure and diastolic pressure while the levels of urine leptin were related to the amount of urinary protein. [Conclusions]The results suggest that the increased serum leptin is correlated with hypertensive disorder complicating pregnancy, while the increasing levels of urinay leptin in pregnant women may link to impaired renal function.