氟比洛芬酯用于防治丙泊酚注射痛的临床观察

Preventive Effect of Flurbiprofen Axetil on the Pain of Propofol Injection

目的观察氟比洛芬酯防治丙泊酚注射痛的疗效。方法将100例ASAⅠ-Ⅱ级择期手术患者随机分成4组,每组25例。各组患者于注射丙泊酚前均在前臂用止血带人为阻断血流2 min后分别静推利多卡因40 mg(A组)、甲氧氯普胺10 mg(B组)、氟比洛芬酯50 mg(C组)、生理盐水5 mL(D组),注射完毕1 min后松开止血带,静推丙泊酚注射液行麻醉诱导,观察每组疼痛发生率,并根据Ambesh法评分。结果A、B、C组的注射痛发生率和疼痛程度明显低于D组,差异有统计学意义(P<0.01)。结论氟比洛芬酯能有效降低丙泊酚注射痛的发生率并减轻疼痛程度,与利多卡因、甲氧氯普胺的疗效相当。

Objective To observe the clinical effect of flurbiprofen axetil for reducing pain on injection of propofol. Methods 100 cases of ASA Ⅰ-Ⅱ grade patients scheduled to undergo se- lective operations were divided randomly into 4 groups to receive lidocaine 40 mg（Group A） ,metoclopramide 10 mg（Group B）,flurbiprofen axetil 50 mg（Group C）,or placebo 5 mL（Group D） respectively, preceded by venous occlusion with a rubber tourniquet on the forearm for 2 minutes. After injection for 1 minute,the tourniquet was released, and followed by the administration of propofol for the induction of general anesthesia. The incidence of injection pain was recorded, and the pain score was evaluated by the Ambesh system. Results The incidence and severity of pain was significantly lower in the group A,group B and group C than those in the group D（P〈0. 01）. Conclusion Flurbiprofen axetil injection could efficiently reduced the incidence and degree of the injection pain of propofol, equal to the effect of lidocaine or metoclopramide.