微波辐射下氨磺酸催化水相合成3,3-亚芳基双(4-羟基香豆素)

Synthesis of 3,3-Arylidene Bis(4-hydroxycoumarin) Catalyzed by Sulfamic Acid in Aqueous Media under Microwave Irradiation

在水介质中,用氨磺酸作催化剂并经微波辐射,使芳醛与4-羟基香豆素反应合成3,3-亚芳基双(4-羟基香豆素),具有催化剂易得、环境友好、后处理简便、反应时间短和产率高等优点.

A series of 3,3-arylidene bis（4-hydroxycoumarins） with 75%-96% yields were synthesized by the reaction of aromatic aldehydes with 4-hydroxycoumarin using sulfamic acid as catalyst in aqueous media under microwave irradiation. The procedure has the advantages of high yield, short reaction time, environmental begin and easy work-up. Their structures were confirmed by IR, lH NMR, ^13C NMR spectra and elemental analysis.