药物自我处置程式训练改善精神分裂症患者生活质量的对照研究

A Randomized Control Study on Quality of Life with Medication Self-management Module for Patients with Schizophrenic

目的探讨药物自我处置程式对精神分裂症患者生活质量的影响。方法将66例住院非急性期精神分裂症患者随机分为训练组(n=33)和对照组(n=33)。在抗精神病药物治疗不变的前提下,训练组按照Liberman编写的《药物自我处置程式》进行分组训练8周,8周后两组随访6个月。采用自制的药物依从性评分表和生活质量综合评定问卷(GQOLI-74)对两组患者进行评估。结果第8周及6个月时训练组治疗依从性、GQOLI-74总分高于入组时(P<0.01),显著高于对照组8周、6个月时(P<0.05)。训练组6个月时比8周时的治疗依从性稍下降,但差异无统计学意义(P>0.05)。对照组6个月时治疗依从性下降,与8周时比较差异有统计学意义(P<0.01)。结论药物自我处置程式训练能提高患者的治疗依从性,提高其生活质量。

Objective To explore the impact of medication self-management module on quality of life of patients with schizophrenia. Methods 66 inpatients with schizophrenia in their non-acute stage were randomly divided into training group （n = 33 ）and control group （ n = 33 ）. Both of groups received the anti-psychotics therapy. Medication self-management module was only given to the training group for 8 weeks. All subjects were follow up for 6 months and evaluated with self-made drug treatment compliance rating scale, Generic Quality of Life Inventory-74 （GQOIL-74）. Results Treatment compliance and the total scores of GQOIL-74 of training group were significantly higher than that of before project and control group after 8 weeks and 6 months （ P 〈 0.05 ）. Treatment compliance of control group at 6 months was significantly lower than that of 8 weeks（ P 〈 0.01 ）, and the training group had a little improvement but no statistical significance（ P 〉 0.05 ）. Conclusion Medication self-management module could significantly improve treatment compliance, and the quality of life of patients with schizophrenia.