摘要
为了解重庆地区自身免疫性甲状腺疾病(AITD)患者外周血sFas与sFasL的表达情况与尿碘的关系,探讨AITD发病的机制,采用病例对照研究,检测并分析各组人群外周血sFas和sFasL及尿碘的含量。结果表明,GD与HT组体内的碘营养状况高于对照组(P<0.000 1),GD组的sFas含量高于对照组,GD和HT组的sFasL含量高于对照组,其差异具有统计学意义。外周血中sFas与sFasL之间存在负相关关系,随着尿碘含量的增高,sFas含量下降,sFasL含量升高。提示AITD患者体内存在高碘营养状况,高碘可能导致细胞的过度凋亡,从而诱发AITD。
To know the relationship between urine iodine of patients with autoimmune thyroid disease （AITD） and the expression of sFas / sFasL in the blood taking a case - control study, sFas, sFasL and urine iodine levels in each group were detected and analyzed, The results show that the iodine nutritional status of GD and HT group are higher than the control group （P 〈 0. 000 1 ）, the content of sFas in GD Group is higher than the control group, the sFasL of GD and HT group are higher than the control group. The difference is statistically significant. There is the negative relationship between sFas and sFasL. The content of sFas will be decreased; sFasL will be increased with the increase of urine iodine. It concludes： Iodine nutritional status may be higher in the AITD patients. High iodine may lead to excessive apoptosis of cells and induce AITD.
出处
《广东微量元素科学》
CAS
2009年第11期13-17,共5页
Trace Elements Science
基金
重庆市"十一五"科技发展规划重大专项(CSTC
2007AB5034)
重庆医科大学2007年度校级课题基金(XBYB2007072)
