急性脑梗死患者治疗前后血浆Hcy、CGRP和ET-1检测的临床意义

Clinical Significance of Changes of Plasma Hcy,CGRP and ET-1 Levels After Treatment in Patients with Cerebral Infarction

目的:探讨了急性脑梗死患者治疗前后血浆Hcy、CGRP和ET-1水平的变化及意义。方法:应用放免法和ELISA对33例急性脑梗死患者进行了治疗前后血浆Hcy、CGRP和ET-1的检测,并与35名正常健康人作比较。结果:在治疗前,急性脑梗死患者血浆Hcy、ET-1水平非常显著地高于正常人组(P<0.01),而CGRP水平则显著地低于正常人组(P<0.01);治疗后,则与正常人组比较无显著性差异(P>0.05)。结论:检测急性脑梗死患者血浆Hcy、CGRP和ET-1水平的变化对了解病情、观察预后均有重要的临床价值。

Objective To study the clinical significance of changes of plasma Hcy,CGRP and ET-1 levels after treatment in patients with cerebral infarction.Methods Plasma CGRP,ET-1（with RIA） and plasma Hcy（with ELISA） levels were determined in 33 patients with cerebral infarction both before and after treatment as well as in 35 controls.Results Before treatment,in the patients the plasma Hcy,ET-1 levels were significantly higher than those in controls（P0.01）.While the plasma CGRP levels were significantly lower（P0.01）.After 2 weeks of treatment,the levels were markedly corrected and were not significantly different from those in controls（P0.05）.Conclusion Plasma Hcy,CGRP and ET-1 levels changes could reflect the disease status as well as the progress of disease in patients with cerebral infarction.