慢性前列腺炎患者治疗前后血清IL-8、IL-1β和TNF-α检测的临床意义

Clinical Significance of Determination of Changes of Serum IL-8,IL-1β and TNF-α Levels After Treatment in Patients with Chronic Prostatitis

目的:检测了慢性前列腺炎患者治疗前后血清IL-8、IL-1β和TNF-α水平的变化及意义。方法:应用放免法和酶免法对40例慢性前列腺炎患者进行了治疗前后血清IL-8、IL-1β和TNF-α检测,并与35名健康人作比较。结果:慢性前列腺炎患者在治疗前血清IL-8、IL-1β和TNF-α水平均非常显著地高于正常人组(P<0.01),经综合治疗2周后,除TNF-α水平与正常人组比较无差异外,血清IL-8、IL-1β水平与正常人组比较仍有显著性差异(P<0.05)。结论:血清IL-8、IL-1β和TNF-α可能以不同的方式参与慢性前列腺炎的发生与发展,其检测对了解病情和指导治疗、预后观察均具有重要的治疗价值。

Objective To study the significance of changes of serum IL-8,IL-1β and TNF-α levels after treatment in patients with chronic prostatitis.Methods Serum TNF-α（with RIA）.IL-8,IL-1β（with ELISA） levels were determined in 40 patients with chronic prostatitis both before and after treatment as well as 35 controls.Results Before treatment,the serum IL-8,IL-1β and TNF-α levels in the patients were significantly higher than those in controls（P〈0.01）.After 2 weeks treatment,the IL-8 and IL-1β levels dropped markedly,but remained significantly higher than those in controls（P〈0.05）.However,the serum TNF-α levels dropped more and were not much different from those in controls（P〈0.05）.Conclusion IL-8,IL-1β and TNF-α could take part in the pathogenesis in chronic prostatitis in various ways and determination of these levels clinically important.