脑梗死患者治疗前后血浆Hcy和血清NSE、IL-8测定的临床意义

Clinical Significance of Determination of Changes of Plasma Hcy and Serum NSE,IL-8 Levels After Treatment in Patients with Cerebral Infarction

目的:探讨了脑梗死患者治疗前后血浆Hcy和血清NSE、IL-8水平的变化及意义。方法:应用酶免法和放射免疫分析对32例脑梗死患者进行了治疗前后血浆Hcy和血清NSE、IL-8测定,并与35名正常健康人作比较。结果:在治疗前脑梗死患者血浆Hcy和血清NSE、IL-8水平均非常显著地高于正常人组(P<0.01),经3个月治疗后与正常人组比较仍有差异(P<0.05)。结论:脑梗死的发生、发展与Hcy、NSE和IL-8水平密切相关。

Objective To explore the changes of plasma Hcy and serum NSE,IL-8 levels after treatment in patients with cerebral infarction.Methods Plasma Hcy（with ELISA） and serum NSE,IL-8（with RIA） levels were determined in 32 patients withcerebral infarction both before and after treatment as well as in 35 controls.Results Before treatment,the plasma Hcy and serum NSE,IL-8 levels in the patients were significantly higher than those in controls（P〈0.01）.After 3 month＇s treatment,the levels though dropped markedly,still remained significantly higher（P〈0.05）.Conclusion Plasma Hcy and serum NSE,IL-8 levels might be of prognostic value in patients with cerebral infarction.