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假丝酵母C-5的不对称生物还原作用研究 被引量：1

Study on the Asymmetric Bioreductions of Candida sp. C 5
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摘要 生命与手性密切相关，凡涉及到生命现象和生理活性物质几乎都离不开有关分子的空间立体构型问题，不同构型的手性分子具有不同的生理活性。利用酶反应的立体专一性，用生物转化法取代部分传统的化学方法，可以很方便地制备具有所需手性中心的化合物。因此，近年来生物转化... Eight strains of microorganisms which have activity of dicarbonyl compound reduction were isolated from hundreds of strains of yeasts and fungi, in which Candida sp. C 5 showed the highest activity and good regioselectivity and stereoselectivity. The effect of reaction time, biomass, reaction solution, pH, aeration and temperature on the bioreduction was investigated.
作者 李祖义 顾建新 潘冰峰
机构地区 中国科学院上海有机化学研究所
出处 《生物工程学报》 CAS CSCD 北大核心 1998年第4期460-463,共4页 Chinese Journal of Biotechnology
关键词 假丝酵母C-5 不对称生物还原 还原率 Biocatalysis, bioreduction, Candida sp.
分类号 Q936 [生物学—微生物学]
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  • 8Edin M, Steinreiber J, Backvall J E. Asymmetric catalysis special feature part Ⅱ: One-pot synthesis of enantiopure syn-1, 3-diacetates from racemic syn/anti mixtures of 1,3-diols by dynamic kinetic asymmetric transformation [ J ]. Proceedings of the National Academy of Sciences USA, 2004,101 : 5761 - 5766.
  • 9Ahmad K, Koul S, Taneja S C, et al. Enzyme directed diastereoselectivity in chemical reductions:Studies towards the preparation of all four isomers of 1-phenyl- 1,3-butanediol [ J ]. Tetrahedron: Asymmetry, 2004,15 (11) :1685 - 1692.
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引证文献1

生物工程学报
1998年 第4期

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