姜黄素对心绞痛患者血清脂联素和血管内皮功能的影响

Influence of curcumin on serum adiponectin and vascular endothelial function in angina pectoris patients

目的研究姜黄素对心绞痛患者血清脂联素水平和血管内皮功能的影响。方法120例心绞痛患者随机分为治疗组60例、对照组60例。2组均予调脂、抗凝、抗血小板聚集等常规治疗,治疗组在常规治疗基础上加用姜黄素胶囊口服,2组疗程均为30 d。分别于治疗前后采集空腹静脉血,测定血清脂联素、假性血友病因子(vWF)、一氧化氮(NO)、白细胞介素6(IL-6)的水平。结果2组治疗后血清脂联素、NO水平升高,vWFI、L-6水平降低,治疗组治疗前后比较有显著性差异,而对照组无显著性差异。结论姜黄素能有助于提高血清脂联素水平,改善心绞痛患者的血管内皮功能。

Objective It is to study the influence of curcumin on serum adiponectin level and vascular endothelial function in angina pectoris patients.Methods 120 patients with angina pectoris were randomly divided into treatment group and control group in which there were 60 patients.The two groups were both treated with conventional therapy including regulating blood fat,anticoagulation,resisting platelet aggregation and so on.The treatment group was added curcumin capsule taken orally based on conventional therapy.The courses of treatment of the two groups were both 30 d.The venous blood on an empty stomach in the two groups was gathered before and after treatment.The levels of serum adiponectin,von Willebrand factor（vWF）,nitric oxide（NO） and interleukin-6（IL-6） in the two groups were determind.Results After treatment in the two groups,the levels of serum adiponectin and NO heightened and the levels of vWF and IL-6 lowered.There was significant difference in treatment group between before and after treatment,but there was no significant difference in control group between before and after treatment.Conclusion Curcumin can make for heightening the level of serum adiponectin and improving vascular endothelial function in angina pectoris patients.