2型糖尿病患者并发脑梗死危险因素研究

Risk factors study of type 2 diabetics complicated with cerebral infarction

目的研究2型糖尿病患者并发脑梗死的危险因素。方法以2型糖尿病合并脑梗死62例(Ⅱ组)患者与2型糖尿病无脑梗死78例(Ⅰ组)进行回顾性分析。2组病例均记录血压、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)。结果Ⅱ组收缩压、舒张压、2 h PG、TC、TG、LDL-C、HDL-C与Ⅰ组比较均有显著性差异(P均<0.05)。单纯收缩期高血压与其余高血压患者在Ⅱ组无显著性差异(P>0.05);所有高血压与无高血压患者在Ⅰ组有显著性差异(P<0.05)。2组患者FPG及脉压均无显著性差异(P均>0.05)。结论高血压、胰岛素抵抗、高血糖、高血脂是2型糖尿病并发脑梗死的危险因素,应强调综合多重危险因素的控制,提倡健康的生活方式,预防脑梗死的发生,达到有效降低糖尿病终点事件发生率的目的。

Objective It is to study the risk factors of type 2 diabetics complicated with cerebral infarction.Methods 140 patients were retrospectively analyzed.62 patients with type 2 diabetics complicated with cerebral infarction were in group Ⅰ and the other 78 patients with type 2 diabetics without complicated with cerebral infarction were in group Ⅱ.Blood pressure,fasting plasma glucose （FPG）,2 h plasma glucose（2 h PG）,cholesterol（TC）,triglyceride（TG）,low density lipoprotein cholesterol（LDL-C） and high density lipoprotein cholesterol（HDL-C） in the two groups were recorded.Results There were all significant differences in systolic pressure,diastolic pressure,2 h PG,TC,TG,LDL-C and HDL-C between the two groups（all P〈0.05）.There was no significant difference between isolated systolic hypertension patients and other hypertension patients in group Ⅱ（P〉0.05）.There was significant difference between all hypertension patients and no hypertension patients in group Ⅰ（P〈0.05）.There was no significant difference in FPG and pulse pressure between the two groups（all P〈0.05）.Conclusion Hypertension,insulin resistance,hyperglycosemia,hyperlipemia are the risk factors of type 2 diabetics complicated with cerebral infarction.The incidence rate of severe complications of diabetics can be effectively lowered through controlling multiple risk factors,advocating healthy life style and preventing beforehand cerebral infarction.