番石榴叶治疗小儿轮状病毒肠炎的临床疗效观察

Clinical curative effect observation of Folium Psidii Guajavae on children with rotavirus enteritis

目的观察番石榴叶治疗小儿轮状病毒(HRV)肠炎的临床疗效以及可能的不良反应。方法68例HRV肠炎患儿随机分为观察组和对照组,对照组采用常规方法治疗,即补液、口服思密达、微生态制剂;观察组在常规方法治疗的基础上,加服番石榴叶煎剂。比较2组患儿的疗效(包括止泻效果、食欲恢复情况、大便HRV抗原转阴率)以及可能出现的不良反应,如活力差、腹胀、便秘、心肝肾功能改变等。结果观察组止泻时间为(32.1±8.2)h,对照组止泻时间为(74.2±9.3)h。治疗开始1周后大便HRV抗原转阴率观察组为88%,对照组为68%。观察组在止泻时间以及HRV抗原转阴率方面均显著优于对照组,均有显著性差异。2组患儿治疗过程中及治疗后1周均未发现活力低下、腹胀、便秘的改变,治疗后1周复查心肝肾功能无显著性差异。结论番石榴叶治疗小儿HRV肠炎有很好的临床疗效,在一定的治疗剂量下,其不良反应尚未发现,值得临床推广。

Objective It is to observe the clinical curative effect and possible untoward reaction of Folium Psidii Guajavae on children with rotavirus（HRV） enteritis.Methods 68 children with HRV enteritis were randomly divided into observation group and control group.The control group was treated with routine therapy including fluid replacement,smecta,and microecology praeparatum.The observation group was added with Folium Psidii Guajavae based on the therapy of control group.The curative effect including checking diarrhea,appetite recovery and stool HRV antigen darkening rate and the possible untoward reaction including weak vitality,abdominal distension,constipation and the changes of heart function, hepatic function and renal function were compared.Results The time of checking diarrhea in observation group was（32.1±8.2） h and that in control group was（74.2±9.3） h.One week after treatment,the stool HRV antigen darkening rate in observation group was 88% and that in control group was 68%.There were both significant differences on the time of checking diarrhea and the stool HRV antigen darkening rate between observation group and control group.No changes of weak vitality,abdominal distension and constipation were discovered in the two groups during treatment and one week after treatment.Heart function,hepatic function and renal function were rechecked one week after treatment and there was no significant difference.Conclusion Folium Psidii Guajavae has commendable clinical curative effect on children with HRV enteritis.In defined therapeutic dose,Folium Psidii Guajavae is safe without untoward reaction and is worth clinical generalization.