肿瘤细胞粘附、迁移与转移的相关性

The Relationship Between Adhesion, Migration of Cancer Cells and Metastasis.

肿瘤细胞的粘附、迁移能力与癌转移密切相关．细胞粘附分子选择素、整合素、免疫球蛋白超家族及钙粘素介导同型或异型细胞间以及细胞与基质间的粘附，其在肿瘤细胞表面表达数量或分布方式的改变直接或间接影响着转移潜能，是肿瘤细胞从原发瘤脱落以及着床的关键性环节．肿瘤细胞的迁移能力被认为是癌转移的限速环节．一般情况下，肿瘤细胞在体内或体外的迁移能力与其转移潜能呈正相关性，肿瘤细胞通过对迁移刺激物的趋化性及趋触性应答而完成向远离器官的转移。

The ability of tumor cell to adhere and migrate is closely related to metastasis. Cell adhesion molecules, such as selectins, integrins, Ig superfamily and cadherins mediate cell to cell and cell to matrix interactions. Cell adhesiveness changed by the different expression or distribution of cell adhesion molecules on tumor cell surfaces affects the metastatic potential directly or indirectly, so it is very important for tumor cells to separate from primary lesion and lodgement. Tumor cell migration is thought to be a major limiting step in metastasis. In general, the ability of tumor cells to migrate in vivo or in vitro is positively correlated with their metastatic potential. Once stimulated by motile factor, tumor cells can promote their migration by themselves through chemotaxis and haptotaxis, the molecular mechanism of which is unclear at present yet.