NHE基因家族的研究进展

Advances in the Study of the NHE Gene Family .

Ｎａ＋／Ｈ＋交换泵（Ｎａ＋／Ｈ＋ｅｘｃｈａｎｇｅｒ，ＮＨＥ）是存在于所有脊椎动物细胞中的重要跨膜蛋白，该蛋白质涉及细胞的多种功能，包括细胞内ｐＨ值调节、细胞体积的控制以及离子转运等．目前已克隆了五个亚型ＮＨＥ的ｃＤＮＡ，它们构成了脊椎动物细胞离子转运泵的一个基因家族．这五个亚型的表达水平及活性可受多种因素的调节．在肿瘤、高血压及糖尿病等疾病中，已发现ＮＨＥ１亚型的表达水平和活性显著增高．因此，研究ＮＨＥ１的转录及活性调节机制，将可能为这些疾病的诊治提供新的手段．

Na +/H + exchangers (NHE) are vital transmembrane transporters involved in multiple cellular functions including the regulation of intracellular pH, the control of cell volume and ion transport. Five isoforms of Na +/H + exchangers have been cloned and characterized to date; they constitute a new gene family of vertebrate transporters. And these isoforms are highly regulated by a remarkably wide variety of stimuli which can modulate their expression level and activity. Among the isoforms, the increased expression level and activity of human NHE 1 have been found to play a role in some critical diseases, such as tumor, hypertension and diabetes. Thus it may provide a new way of diagnosing and treating for these diseases by investigating on the transcription modulation of NHE 1 gene and the activity regulation of the exchanger .