p33^(ING1)蛋白在食管鳞状细胞癌中异位表达的临床病理意义

Study on the clinicopathological significance of abnormal expression of p33^(ING1) protein in esophageal squamous cell carcinoma

目的探讨p33ING1蛋白在食管鳞状细胞癌中异常表达的临床病理意义。方法采用免疫组化的方法检测20例正常食管黏膜组织和64例食管鳞状细胞癌组织中p33ING1蛋白的表达并分析其临床病理意义。结果p33ING1蛋白在食管鳞状细胞癌中的阳性表达部位主要在细胞核和细胞质中,其阳性表达率为35.94%(23/64),而在正常食管黏膜组织中主要表达在细胞核中,阳性表达率为95.00(19/20),二者比较差异有统计学意义(P<0.05)。食管鳞状细胞癌中淋巴结转移阳性表达率为15.00%,淋巴结无转移阳性表达率为45.45%,二者比较差异有统计学意义(P<0.05)。p33ING1蛋白的表达与患者性别、年龄及肿瘤大小、位置和组织学分级均无相关性(P>0.05)。结论p33ING1蛋白在食管鳞状细胞癌的发生发展中可能有重要的作用,其表达部位由细胞核转移到细胞质可能是其抑瘤功能丧失而促使肿瘤发生的主要机制之一。

Objective To investigate the clinicalpathological significance of abnormal expression of p33ING1 protein in esophageal squamous cell carcinoma. Methods The S-p immunohistochemical method was used to detect the expression of p33ING1 from 20 cases of normal esophageal mucous tissue and 64 cases of esophageal squamous cell carcinoma （ESCC）,and to investigate the significance of expression of p33^ING1 protein. Results The site of positive expression of p33^ING1 protein in esophageal squamous cell carcinoma was mainly in nuclear and cytoplasm,and the positive rate was 35.94%（23/64）,but the positive expression site in normal esophageal mucosa was only in nuclear,and the positive rate was 95% （19/20）,there was a significant difference between the two different tissues（P〈0.05）. The positive rate of p33ING1 protein expression was 15.00% in lymph node metastasis group and 45.45% in non-lymph node metastasis group,there was a significant difference between the two groups （P〈0.05）. The p33ING1 protein expression was not correlated with patient＇s gender,age and tumor size,location and histological classification （P〉0.05）. Conclusion The p33^ING1 protein may play an important role in the genesis and development of esophageal squamous cell carcinoma,one of the most important mechanisms of tumor genesis may be the translation of the p33ING1 protein from nuclear to cytoplasm.