摘要
研究了溶氧对生米加链霉菌变株生物转化螺旋霉素的影响，确定这种生物转化反应是显著的需氧过程，发酵过程具有与一般抗生素发酵不同的两个摄氧率高峰．根据溶氧对菌体生长和转化反应的双重影响，初步建立了分阶段溶氧控制的发酵过程，终转化率提高了８％，并将发酵时间缩短了约１／６．
The effect of dissolved oxygen (DO) on the spiramycin biotransformation by the mutant strain of S. mycarofaciens was studied. The reaction of biotransformation was a remarkable oxygen-consumed process. Two peaks of oxygen uptake rate were observed in the whole fermentation course. The method of controlling the dissolved oxygen concentration in the different phases was developed. The highest biotransformation ratio 80% was obtained and the total fermentation time was cut down by 1/6.
出处
《化工冶金》
CSCD
北大核心
1998年第4期350-354,共5页
