摘要
目的:探讨获得性噬血细胞综合征(HPS)合并多脏器功能障碍综合征的临床特点,提高对本病的认识。方法:对10例HPS患者的临床病历资料进行综合分析。结果:10例患者均符合HLH-2004获得性HPS的诊断标准,同时伴有3~6个脏器功能障碍,SOFA评分4~12分,平均8.8±2.2分。10例均伴有NK细胞活性减低和sCD25水平升高,经治疗后存活4例,死亡6例。结论:对发热原因不明、多脏器功能障碍的患者,若血细胞减少、肝脾肿大、血清铁蛋白升高,并发NK细胞活性减低和sCD25水平升高,应警惕噬血细胞综合征。早期诊断和及时治疗能够改善预后。
Objective To investigate the clinical features of acquired hemophagocytic syndrome (HPS) complicating multiple organ dysfunction syndrome (MODS). Methods: Clinical medical records of 10 eases with HPS were analyzed. Results: All cases met the diagnostic criteria of HLH-2004 acquired HPS and presented with 3 to 6 organs dysfunction, SOFA score was 4-12, the median score was 8. 8 ±2. 2. All eases had low activity of NK cells and high level of sCD25. Four of 10 patients survived and 6 died after treatments. Conclusions: HPS should be alerted when patients have a fever of unknown origin, MODS, low activity of NK ceils and high level of sCD25. Early diagnosis and prompt treatment can improve the prognosis.
出处
《内科急危重症杂志》
2009年第6期299-301,共3页
Journal of Critical Care In Internal Medicine