利培酮与奎硫平治疗首发精神分裂症对照研究

Comparative Study of Risperidone and Quetiapine in the Treatment of First-episode Schizophrenia

目的探讨利培酮与奎硫平治疗首发精神分裂症的临床疗效及安全性。方法将60例患者随机分为利培酮组与奎硫平组各30例,治疗6周,采用阳性与阴性症状量表(PANSS)评定疗效,采用副反应量表(TESS)评定副反应。结果利培酮组总有效率为83.3%,奎硫平80%,两组差异无显著性(P>0.05)。利培酮组主要副反应是肌强直,表情呆板;奎硫平组主要副反应是困倦,头晕。结论利培酮与奎硫平治疗首发精神分裂症均有良好疗效,两药副反应均较轻。

Objective To compare the efficacy and safety of Risperidone and Quetiapine in the treatment of first-episode schizophrenia.Methods Sixty inpatients with first-episode schizophrenia were randomly allocated to Risperidone group （n=30） and Quetiapine group（n=30） respectively, and the duration of treatment was 6 weeks. The positive and negative syndrome scale （PANSS） and treatment emergent side effect scale （TESS） were used to evaluate the efficacy and side effects. Results The efficacy rates of Risperidone and Quetiapine were 83.3% and 80% respectively after 6 week＇s treatment. There was no significant difference in the efficacy rates between the two groups （P〉0.05）. The side effe cts of Risperidone were myotonia and dull expression, and those of Quetiapine were dizziness and drowsy. Conclusion Risperidone is as effective as Quetiapine in the treatment of first-episode schizophrenia, and the side effects were slighter.