阿立哌唑对老年精神分裂症患者生活质量的影响

Effect of Aripiprazole on Quality of Life in Aged Patients with Schizophrenia

目的比较阿立哌唑与利培酮对老年精神分裂症患者生活质量的影响。方法将60例老年精神分裂症患者随机分为两组各30例,分别给予阿立哌唑和利培酮治疗,疗程8周。用阳性与阴性症状量表(PANSS)及副反应量表(TESS)评定疗效及不良反应,生活质量综合评定问卷74(GQOLI-74)评定生活质量。结果阿立哌唑与利培酮治疗精神分裂症均有显著疗效,但阿立哌唑组在改善(CQOLI-74)总分、躯体健康及社会功能维度均优于利培酮组。利培酮组不良反应比阿立哌唑组多。结论阿立哌唑与利培酮对老年精神分裂症疗效相当,阿立哌唑不良反应少,安全性高,对提高老年精神分裂症患者生活质量的效果优于利培酮。

Objective To compare the effect of Aripiprazole and Risperidone on quality of life in aged patients with schizophrenia. Methods A total of 60 patients with schizophrenia were randomly divided into two groups to be treated by Aripiprazole （n=30） or Risperidone （n=30） and to be evaluated with general quality of life inventory （CQOLI-74）, positive and negative symptom scale（PANSS） and treatment emergent symptom scale（TESS） for 8 weeks. Results The quality of life improved in the schizophrenia patients who treated with Aripiprazole and Risperidone. There was significant difference in CQOLI-74 between the two groups. Aripiprazole was significantly better than Risperidone. Conclusion The efficacy of Aripiprazole in aged schizophrenic patients was similar to risperidone. The side effect was little in Aripiprazole group, so the safety of Aripiprazole was high. Aripiprazole was superior to improve the life quality of aged patients with schizophrenia to risperidone.