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非末端羟基取代均三唑并噻二嗪的合成研究

Synthesis and Characterize of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines
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摘要 以缬草酸内酯(1,4-戊内酯)为原料,合成中间体3-(3-羟丁基)-4-氨基-5-巯基-1,2,4-三唑1;1与ω-卤代的芳酮缩合得到了8个全新三唑并噻二嗪类化合物2a-2h,其结构经1H NMR和MS进行了表征。 Eleven novel 6 - aryl -3 - (3 - hydroxybutyl) -7H - 1,2,4 - triazolo [ 3,4 - b] [ 1,3,4 ] thiadiazines were synthesized by the reaction of 4 - amino - 3 - (3 - hydroxybutyl) - 1H - 1,2,4 - triazole - 5 (4H) - thione with substituted ω -bromoacetophenones or co -chloroacetophenone. All the products had been characterized by1 H -NMR and MS.
出处 《广州化工》 CAS 2009年第9期84-85,92,共3页 GuangZhou Chemical Industry
基金 浙江省自然科学基金(No.M203149) 课题负责人:张力学教授
关键词 合成 3-羟丁基 1 2 4-三唑 1 2 4-三唑并[3 4-b][1 3 4]噻二嗪 synthesis 3 - hydroxybutyl 1,2,4 - triazole 1,2,4 - triazolo [ 3,4 - b ] [ 1,3,4 ] thiadiazines
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  • 1Ashour, F. A. , Almazroa, S. A. Synthesis of certain thiosemicarbazide and triazole derivatives as potential antimicrobial agents [ J ]. IL Farmaco, 1990, 45:1207-1218.
  • 2李新芝,司宗兴.有生物活性的三唑类化合物的研究进展[J].农药,2003,42(1):4-5. 被引量:7
  • 3Goswami, B. N. , Kataky, J. C. S. , Boruah, J. N. , et al. Synthesis and antifungal activities of some new substituted 1,2,4 - triazoles and related compounds[J]. J. Indian Chem. Soc. , 1984, 61(6) : 530 - 533.
  • 4Eweiss, N. F., Bahajaj, A. A., Elsherbini, E. A. Synthesis of heteroeyeles. Part Ⅵ. Synthesis and antimicrobial activity of some 4 - amino -5 -aryl - 1,2,4 - triazole -3 - thiones and their derivatives [ J ]. J. Heteroeyelie Chem. , 1986, 23(5): 1451 -1458.
  • 5El - Dawy, M. A. , Omar, A. , Mohsen M. E. , et al. Potential broad spectrum anthelmintics. Ⅳ : Design, synthesis, and antiparasitic screening of certain 3,6 - disubstituted - 7 H - s - triazolo [ 3,4 - b ] [ 1,3,4 ] thiadiazine derivatives [ J ]. J. Pharmaceutical Sciences. , 1983, 72(1) : 45 -50.
  • 6Eweiss, N. F., Bahajaj, A. A. Synthesis of heterocycles. Part Ⅶ. Synthesis and antimicrobial activity of some 7 H - s - triazolo [ 3,4 - b ] [ 1,3,4 ] thiadiazine and s - triazalo [ 3,4 - b ] [ 1,3,4 ] thiadiazole derivatives[J]. J. Heterocyclic Chem. , 1987, 24(4) : 1173 - 1182.
  • 7Chande, M. S. , Karnik, B. M. , Ganguly, N. Synthesis and antimi- crobial screening of new s - triazolothiadiazines[J].J. Indian Chem. Soc., 1990, 67(8) : 695 -696.
  • 8Bayoumy, B. E. , El -Bahie, S. , Youssif, S. Bridged head nitrogen compounds. Synthesis and biological activity of some novel oxadiazolo - , triazolothiadiazinio - and triazolothiadiazolo thienopyrimidine derivatives[J]. Polish J. Chem., 1991,65(7-8): 1297-1302.
  • 9Jin, J. Y. , Zhang, L. X. , Zhang, A. J. et al. Synthese and biologi- cal activity of some Novel Derivatives of 4 - Amino - 3 - ( D - galactopentitol - 1 - yl ) - 5 - mercapto - 1,2,4 - triazole [ J ]. Molecules, 2007, 12: 1596-1605.
  • 10Zhang, L. X.,Jin, J.Y.,Zhou, S. N.,etal. 3-[6-(4-Bromo- phenyl) -7H - 1,2,4 - triazolo[ 3,4 - b] [ 1,3,4] thiadiazin - 3 - yl]propanol[J]. Acta Cryst., 2006, E60:01224-01225.

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