FAK与β-catenin在子宫内膜癌中的表达及临床意义

Expression and significance of FAK and β-catenin in endometrial adenocarcinoma

目的:探讨粘着斑激酶(FAK)和β-连环素(β-catenin)在子宫内膜癌中的表达及临床意义。方法:采用免疫组织化学二步法,研究FAK和β-catenin在63例子宫内膜癌、30例正常子宫内膜组织中的表达情况。结果:FAK和β-catenin在子宫内膜癌组织中的阳性表达率分别为84.1%、63.5%,在正常子宫内膜组织中的阳性表达率分别为16.7%、13.3%,在子宫内膜癌组织中的表达均高于正常内膜组织(P<0.05)。FAK与β-catenin的表达在不同肌层浸润深度、淋巴结转移及FIGO分期的子宫内膜癌中差异有统计学意义(P<0.05)。β-catenin的表达在不同组织病理分级的子宫内膜癌中差异有统计学意义(P<0.05)。在63例子宫内膜癌患者中,FAK与β-catenin的表达呈正相关(r=0.3653,P=0.0018)。结论:FAK和β-catenin在子宫内膜癌的侵袭与转移中起重要作用,二者的表达异常可以作为预测子宫内膜癌浸润转移及评估预后的指标。

Objective： To investigate the expression of focal adhesion kinase （FAK） and β-catenin in the en- dometrial carcinoma and its clinical significance. Methods. SP immunohistochemical method was used to detect the expression of FAK and β-catenin in 63 cases of endometrial carcinoma and 30 cases of normal endometria. Results： The positive rates of FAK and β-eatenin were 84.1% and 63.5% respectively in endometrial carcinoma, which were higher than those in normal endometria （16.7% and 13.3% respectively）, and the differences were significant （P 〈0.01）. The expressions of FAK and ^-catenin were different in various depth of myometrial invasion, lymph node metastasis and FIGO stage of endometrial carcinoma pa- tients （P〈0.05）, and also the expression of β-catenin was different in several pathological grades （P〈0.05）. There was a positive correlation between FAK and β-catenin in 63 endometrial carcinoma cases （r = 0. 365 3,P =0. 001 8）. Conclusion： FAK and β-catenin play important roles in the development and progression of endometrial carcinoma, and the abnormal expression of them can be used to prognosticate invasion and metastasis and can be used as prognostic indicators of endometrial carcinoma.