5-羟色胺受体对小鼠异氟烷、七氟烷遗忘作用的影响

Effects of 5-HT receptor on isoflurane-and sevoflurane4nduced amnesia in mice

目的探讨5-羟色胺（5-hydmxytry ptamine，5-HT）受体与吸入麻醉药异氟烷、七氟烷遗忘作用的关系。方法建立小鼠腹腔注射异氟烷、七氟烷遗忘模型，在跳台、避暗实验中观察和记录不同剂量5-HT受体拮抗剂（WAY100635）侧脑室注射对跳台潜伏期、步入潜伏期、错误次数的影响。结果侧脑室注射5-HT受体拮抗剂可延长异氟烷、七氟烷所致记忆障碍小鼠的跳台潜伏期（P〈O．05）、步入潜伏期（P〈0．05），减少错误次数（P〈0．05）。结论5-HT受体介导了异氟烷、七氟烷的遗忘作用。

Objective To investigate the relationship between 5-hydroxytry ptamine（5-HT） receptor and the amnesia induced by isoflurane and sevoflurane in mice. Methods Animal models were established by intraperitoneal injection of isoflurane （0.3 ml/ kg） and sevoflurane （3 ml/kg）. After intracerebroventricular injection （icy） of different doses of WAY100635, 5-HT receptor antagonist, step down latency （SDL）, error times in step down test and step through latency （STL）, error times in step through test were observed and recorded. Results Intracerebroventrieular injection of WAY100635 might extend SDL and STL, and reduced error times of isoflurane-and sevoflurane-induced memory impairment in mice. Conclusion 5-HT receptor involves in isoflurane-and sevoflurane-induced amnesia.