伤害性刺激对家兔定量药物脑电图δ频段的影响

Effect of nocuous stimulation on δ-band of quantitative pharmaco-EEG in rabbits

目的观察伤害性刺激对家兔定量药物脑电图（quaxtita tive pharnaco-EEG，QPEEG）8频段的影响。方法壮年家兔，雌雄不拘，随机分为擦拭组、钳夹组、切皮组，建立肌松兔模型后分别给予棉球擦拭、钳夹、切皮刺激。应用QPEEG，采用功率谱分析技术，观察刺激前后兔δ频段功率百分比的变化。结果与刺激前相比，棉球擦拭组δ频段功率百分比差异无统计学意义（P〉0．05）；钳夹组在左枕、右颞脑区δ频段功率百分比降低（P〈0．05），持续至钳夹后30秒～60秒；切皮组在切皮后30秒-2min内，各脑区8频段功率百分比均明显降低（P〈0．05）。结论伤害性刺激引起兔QPEEGδ频段功率百分比降低，提示δ频段功率百分比有可能成为反映镇痛程度的指标。

Objective To study the effects of nocuous stimulation on δ-band of quantitative pharmaco-EEG （QPEEG） in rabbits. Methods Twenty seven rabbits were randomly divided into 3 groups（n=9）, and were ventilated with barbiturate sodium and vecuronium. Animals were stimulated with mopping skin（group M）; holding forceps（group H） or cutting skin（group C）. EEG activity was monitored and processed with the power spectral analysis before and after stimulation. Results The percentage of δ-band power showed no significant changes with stimulation in group M, decreased in the left pulvinar and right temporal bone areas of brain within 0.5-1 min after stimulation in group H （P〈0.05）, and decreased significantly in all the cerebral areas within 0.5,2 min after stimulation in group C （P〈0.05）. Conclusion The results of nocuous stimulation decreasing the percentage of δ-band power indicates that the percentage of δ-band power may become an effective means of monitoring pain stress.