溶栓后结合rhG-CSF治疗急性心肌梗死45例临床研究

Clinical study on the treatment of 45 cases of acute myocardial infarction with thrombolysis and rhG-CSF

目的探讨急性心肌梗死治疗方法及临床疗效。方法将97例急性心肌梗死患者随机分为治疗组45例与对照组52例对照组采用尿激酶溶栓治疗,治疗组在对照组治疗基础上加以重组粒细胞集落刺激因子(rhGCSF)治疗。结果治疗组总再通率、溶栓开始时间<6 h的再通率、溶栓开始时间6～12 h的再通率与对照组比较,差异均无统计学意义(P>0.05)。两组溶栓并发症情况发生的比较,差异均无统计学意义(P>0.05),但治疗组治疗3个月后心肌梗死面积显著小于对照组(P<0.05)。结论急性心肌梗死患者应强调早期溶栓。

Objective To investigate therapeutic method for acute myocardial infarction and its clinical effet. Methods Ninety -seven patients were randomly divided into the treatment group （45 cases） and control group （52 cases）. The patients of control group were treated by the thromoblysis of urokinase, the patients of treatment group were treated by thromoblysis together with rhG - CSF. Results Total recanalization rate, recanalization rate of time of thrombolysis less than 6 hours, that of time of thrombolysis at 6 - 12 hours, compared treatment group with control group, the difference hadn＇t statistical significance（ P 〉 0. 05 ）, compared complication between two groups, the difference hadn＇t statistical significance（ P 〉 0. 05 ）, but after treatment 3 month, the treatment group was less than control group in myocardial infract size（ P 〈 0. 05 ）. Conclusion Acute myocardial infraction should take attention of early thrombolysis, after that, together with the treatment of rhG - CSF, it can decrease the myocardial infarct size effectively.