期刊文献+

静脉营养液中加入小剂量肝素预防新生儿中心静脉置管相关感染 被引量:11

Administration of low-dose heparin in total nutrient admixture prevents central venous catheter-related infections in neonates
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摘要 目的经外周导入中心静脉置管(PICC)是危重新生儿长期静脉营养的有效途径之一,但导管相关性感染(CRI)是其常见并发症。本研究对全合一静脉营养液中加入微量肝素持续输注对PICC相关感染的预防作用进行观察,探讨减少CRI的有效措施。方法83例行PICC置管的患儿分为两组,肝素组(n=43)在营养液中加入肝素0.5U/mL,对照组(n=40)不加肝素,观察两组CRI的发生情况。结果肝素组发生导管堵塞2例(5%),对照组8例(20%);肝素组导管内细菌定植1例(2%),对照组7例(18%);肝素组无一例发生导管相关血流感染,对照组5例(13%),两组相比差异均有显著性(P<0.05)。结论静脉营养液中加入小剂量肝素可减少PICC堵管,预防CRI的发生。 Objective Peripherally inserted central catheter (PICC) is widely used to provide a long-term access for the administration of total parenteral nutrition and medications. Catheter-related infections (CRI) are common complications of PICC. The purpose of this retrospective study was to investigate the role of low-dose heparin added to the total nutrient admixture (CTNA) in the prevention of CRI. Methods Eighty-three neonates who underwent PICC received TNA with (heparin group, n =43) or without heparin (0.5 U/ mL) (control group, n =40). The incidence of CRI was compared between the two groups. Results The incidences of catheter obstruction (5% vs 20% ) and the catheter-tip colonization (7.% vs 18% ) in the heparin group were significantly lower than those in the control group ( P 〈 0.05 ). None of the neonates in the heparin group had clinical evidence of catheter-related bloodstream infection, but 5 cases in the control group (P 〈0.05). Conclusions The administration of low-dose heparin in TNA may decrease the incidences of catheter obstruction and CRI.
出处 《中国当代儿科杂志》 CAS CSCD 北大核心 2009年第12期983-985,共3页 Chinese Journal of Contemporary Pediatrics
基金 国家自然科学基金资助(编号30825039 30770748)
关键词 经外周导入中心静脉置管 导管相关感染 肝素 全合一静脉营养液 新生儿 Peripherally inserted central catheter Catheter-related infection Heparin Total parenteral nutrition Neonate
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参考文献11

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二级参考文献6

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