鼻用皮质类固醇对季节性过敏性鼻炎患者呼吸道一氧化氮浓度的影响

Effect of Topical Steroids on Nasal and Oral Nitric Oxide Production in Patients with Seasonal Allergic Rhinitis

目的测定季节性过敏性鼻炎患者鼻腔和口腔呼出气一氧化氮(nitric oxide,NO)浓度,观察鼻用类固醇治疗对上、下气道一氧化氮浓度的影响。方法使用化学发光法测量28例季节性过敏性鼻炎患者鼻腔和口腔呼出气一氧化氮浓度,经布地奈德鼻喷雾剂(512μg/d,1次/d)治疗14d后重复测量。同期选择80例健康志愿者作为对照。结果季节性过敏性鼻炎患者治疗前后口腔和鼻腔呼出气一氧化氮浓度均显著高于正常对照者。鼻用类固醇激素治疗后鼻腔呼出气一氧化氮浓度较治疗前显著下降(P<0.05),但口腔呼出气一氧化氮浓度较治疗前无明显改变。结论鼻用皮质类固醇短期治疗季节性过敏性鼻炎可降低鼻腔呼出气一氧化氮浓度,对口腔呼出气一氧化氮浓度无显著影响。

Objective The purpose of this study was to determine whether nasal and oral exhaled levels of nitric oxide are increased in patients with seasonal allergic rhinitis and the effect of topical use of steroids on levels of nitric oxide in nasal and oral exhale. Methods We measured the concentration of NO in the exhale from the nose and mouth of 28 patients with seasonal rhinitis who had not received any treatment for at least 4 weeks. All of them were then treated with Budesonide Nasal Spray（512 μg,QD） for 14 days. Measurements were performed before and after the 14 days of treatment. As a control group we evaluated 80 healthy adults. To measure NO we used a chemiluminescence analysis. Results Before and after treatment patients with allergic rhinitis showed a mean nasal and oral exhale NO concentration significantly higher than that of the control group. After 14 days of therapy,a significant decrease of nasal NO concentration,but no significant change of oral NO concentration were observed. Conclusion Intranasal steroid therapy significantly reduces nasal NO production in patients with allergic rhinitis and exhaled nitric oxide may be a useful marker for nasal and oral inflammation in patients with seasonal rhinitis.