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丙型肝炎病毒干扰素抵抗机制研究进展 被引量：3

Progress in Studies on Mechanism of Hepatitis C Virus Resistance to Interferon Treatment
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摘要 干扰素在宿主天然抗病毒防御及外源性治疗过程中具有显著作用。然干扰素作为丙型肝炎病毒(hepatitis C virus,HCV)感染的唯一治疗手段,干扰素抵抗广泛存在。HCV基因编码的病毒蛋白参与其中,使得肝细胞与病毒相互作用,影响干扰素信号传导及靶向抗病毒蛋白发挥作用。 Interferon plays a critical role in the host＇s natural defense against viral infections and in their treatment. Interferon is one of the two drugs that constitute the only antiviral therapy for hepatitis C virus（HCV） infection; however,in a certain proportion of cases the virus is resistant to interferon. Several HCV proteins have been shown to possess properties that enable the virus to evade the interferon-mediated cellular antiviral responses.
作者 任姗 陈新月
机构地区 首都医科大学附属北京佑安医院国际医疗部
出处 《首都医科大学学报》 CAS 北大核心 2009年第6期799-804,共6页 Journal of Capital Medical University
基金 国家"十一五"科技重大专项(2008ZX10002-013)资助项目~~
关键词 干扰素抵抗 丙型肝炎病毒 病毒蛋白 磷酸化 抗病毒作用 治疗过程 氨基酸残基 信号传导 相互作用 信号转导 interferon hepatitis C virus viral protein interferon resistance
分类号 R512.63 [医药卫生—内科学]
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参考文献26

  • 1Jose M C, Michael G, Manuela T P, et al. The role of positive selection in hepatitis C virus [ J ]. Infection, Genetics and Evolution, 2009,9 : 860-866.
  • 2Hideki W, Kazuyoshi N, Nobuyuki E, et al. Amino acid substitutions in PKR-eIF2 phosphorylation homology domain (PePHD) of hepatitis C virus E2 protein in genotype 2a/2b and 1b in Japan and interferon efficacy [J]. Hepatology Res, 2003,26:268-274.
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二级参考文献3

  • 1Kurosaki M,Enomoto, N,Murakami T,et al . Analysis of genotypes and amino acid residues 2 209 to 2 248 of the NsSa region of hepatitis Cvirus in relation to the response to interferorr β therapy[J].Hepatol, 1997, 25:750-753.
  • 2Nakano I,Fukuda Y,Katano Y, et al, Why is the interferon sensitivity-detrnining region( ISDR) system useful in Japan? [J].J Hepatol,199,30:1014-1022.
  • 3Cale MI, Biakely CM, Kwieciszewski B, et al . Contol of PKR protienkinase by the nonstructural 5a protein: molecular mechanism of kinase regulation[J].Mol Cell Biol, 1998,18:5208-5218.

共引文献4

同被引文献33

引证文献3

二级引证文献12

首都医科大学学报
2009年 第6期

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