溃疡性结肠炎患者血浆P选择素的测定及其意义

Study on the plasma P-selectin level and the significance in the patients with ulcerative colitis

目的检测溃疡性结肠炎(UC)患者外周血中P选择素的水平以及其与UC病变程度和范围的关系,探讨其在UC发病机制中的作用。方法采集经临床表现、肠镜及病理诊断的UC患者30例以及正常对照组20例的外周静脉血,ELISA法测定血浆P选择素水平。结果酶联免疫吸附法分析显示:UC组血浆P选择素水平明显高于对照组,UC组患者血浆P选者素水平与病情严重程度呈正相关。结论UC患者血浆中P选择素呈现高表达;血浆P选择素可能成为判断UC严重程度以及临床诊断简单易行的外周生物学指标。

Objective To determine the plasma level of P - selection in patients with ulcerative colitis （UC） and to investigate its clinical significance. Methods ELISA assay was used to determine the plasma P - se- lection level in the peripheral venous blood samples from 30 pathologically confirmed UC patients and 20 normal healthy controls. Results plasma level of P - selection was significantly higher in patients with UC than in normal controls ; plasma level of P - selection was positively correlated with the severity of the disease ; Conclusion Plasma level of P - selection is significantly elevated in patients with UC ; plasma P - selection may be considered as simple biological parameters for the severity and clinical diagnosis of UC.