2Liveremore DM. Linezolid in vitro: mechanism and antibacterial spectrum [J]. J Antimicrob Chemother. 2003,51(S2):119.
3Meagher AK, Forrest A, Rayner CA, et al. Population pharmacokinetics of linezolid in patients treated in a compassionate - use program [J ]. Antimicrob Agents Chemother,2003,47 (2) : 548.
4Eustice DC, Feldman PA, Slee AM. Mechanism of action of DuP- 721, a new antibacterial agent: effects on macromolecular sysntyhesis[J ]. Biochem Biophys Res Commun, 1988,150 : 965.
5Shinabarger DL, Marotti KR, Murray RW, et al. Mechanism of action of oxazolidinones: effects of Linezolid and eperezolid on translation reactions [J ]. Antirnicrob Agents Chemother,1997,41(10) : 2132.
6Swaney S M, Aoki H, Ganoza M C, et al. the oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria [J ].Antimicrob Agents Chernother , 1998,42(12) :3251.
7Kloss P, Xiong L, Shinabarger DL, et al. Resistance mutationd in 23S RNA identify the site of action of the protein synthesis inhibitor Linezolid in the ribosomal peptidyl transferase center [J]. J Mol Biol, 1999,294:93.
8Xiong L, Kloss P, Douthwaite S, et al. Oxazolidlnone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action[J]. J Bacteriol, 2000,182(19): 5325.
9Patal U, Yan YP, Hobbs FW Jr, et al. Oxazolidinones mechanism of action: inhibition of the first peptide bond formation [J]. J Biol Chem, 2001,276(40): 37199.
10Gregory WA, Brittelli DR, Wang CLJ, et al. Antibacterials. synthesis and Structure- activity studies of 3 - aryi - 2 -oxazolidinones. 1. the" B" group [J]. J Med Chem, 1989,32 : 1673.
