摘要
目的:研究厚朴总酚对高钾、组胺和乙酰胆碱所致气管收缩的抑制作用。方法:采用离体豚鼠气管条法,观察厚朴总酚对离体豚鼠支气管条的直接作用以及对高钾、组胺、乙酰胆碱引起的收缩的对抗作用。结果:厚朴总酚对豚鼠支气管条基础张力无明显作用。能抑制氯化钾、乙酰胆碱、磷酸组胺所诱导气管平滑肌收缩,其作用呈剂量依赖性,3×10-5g/mL厚朴总酚最高分别抑制KCl、Ach、His引起的收缩(95.96±3.02)%、(93.98±4.62)%、(92.15±5.66)%。结论:厚朴总酚对气管平滑肌具有显著舒张作用,其机制与细胞膜上的电压依赖性钙通道及细胞内钙的释放有关系。
Objective：To study the influence of Total Phenols from houpo on KCl,histamine（His）,acetylcholine（Ach）-induced contraction of isolated guinea pig trachea in vitro.Methods：Smooth muscle strings of isolated guinea pig trachea were used.The effects of Total Phenols from houpo on contraction induced by KCl,His,Ach were observed.Results：Total Phenols from houpo could significantly inhibited the constraction of isolated guinea pig trachea induced by his,Ach and KCl in a concentration-dependent manner,
but did not affect basal muscle tension.Conclusion： Total Phenols from houpo could significantly distend smooth muscle of isolated guinea pig trachea.The mechanism involved the voltage dependental calcium channels and the release of intracellular calcium.
出处
《辽宁中医药大学学报》
CAS
2010年第1期200-201,共2页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
厚朴总酚
支气管
氯化钾
组胺
乙酰胆碱
total phenols from houpo
potassium chloride
KCl
histamine
Acetylcholine
