乙肝肝硬化患者联合检测血清视黄醇结合蛋白、前白蛋白和白蛋白的临床价值

Detection of serum retinol-binding protein,pre-albumin and albumin in patients with hepatitis B cirrhosis

目的联合检测视黄醇结合蛋白(RBP)、前白蛋白(PA)和白蛋白(ALB)在乙肝肝硬化患者中的血清水平变化,探讨三者的相关性及临床价值。方法应用免疫透射比浊法检测89例乙肝肝硬化患者和35例健康成年人的血清RBP与PA水平,溴甲酚绿法检测血清ALB水平。结果乙肝肝硬化患者的血清RBP、PA和ALB水平均显著低于正常对照组(P<0.01)。血清RBP与PA水平呈正相关(r=0.743,P<0.01),血清RBP、PA亦分别与ALB水平呈正相关(r1=0.602,r2=0.529,P均<0.01)。结论血清RBP、PA和ALB水平与肝功能损害程度相关,可以作为反映肝功能损害程度的指标,而RBP与PA比ALB能更灵敏地反映肝功能损害程度的变化。三者联合检测能更好地判断乙肝肝硬化患者的肝功能状况。

Abstract：Objective To detect the changes in the serum level and investigate the relationship and clinical significance of retinol - binding protein （RBP） , pre - albumin （PA） and albumin （ALB） in patients with hepatitis B cirrhosis. Methods The levels of serum RBP and PA were measured by immunotransmission turbidity and serum ALB was detected by bromo- creosol green method in 89 patients with hepatitis B cirrhosis and 35 healthy controls. Results The levels of serum RBP, PA and ALB in patients with hepatitis B cirrhosis were significantly lower than the control group （ p 〈 0.01 ）. Serum RBP was positively correlated with PA （r = 0. 743, p 〈 0.01 ）. Furthermore, serum RBP and PA were also positively correlated with ALB （r1 =0.602, r2 =0. 529, p 〈0.01）. The levels of serum RBP, PA and ALB were correlated with the degree of liver damage. Conclusion Serum RBP, PA and ALB can be used as an index to reflect the degree of liver damage. Serum RBP is more sensitive to reflect changes of liver function. Combined measurement of serum RBP, PA and ALB can be use- ful markers to evaluate the liver function in patients with hepatitis B cirrhosis.