HSP70、NF-κB在慢性胃病脾胃湿热证中正邪作用的探讨

The Virtuous Effect of Heat Shock Protein 70 and Evil Effect of Nuclear Factor-kappa B in Patients with Chronic Gastric Disease of Pi-Wei Damp-Heat Syndrome Type

近年多项研究认为慢性胃病脾胃湿热证与热休克蛋白70(HSP70)核因子-κB(Nuclear factor-kappa B,NF-κB)存有密切关系,HSP70能够维持细胞自稳,提高机体对肿瘤及外来多种病原体的免疫功能。在幽门螺杆菌(Hp)刺激下胃黏膜中NF-κB表达增多并引起炎症反应,炎症因子又可引起NF-κB表达的增多,从而引起并扩大胃黏膜的损伤。研究表明HSP 70能够阻滞NF-κB的激活与表达。在Hp相关慢性胃病脾胃湿热证与HSP70可能体现了中医"正气"的作用,NF-κB可能体现了中医"邪气"的作用,两者在脾胃湿热证中的表达可能体现了脾胃湿热证"正邪交争"的状态。

It has been proved in recent studies that the chronic gastric disease（CGD） of Pi-Wei damp-heat syndrome type（CGD-PWDH） is closely related with heat shock protein 70（HSP70） and nuclear factor-kappa B（NF-κB）.HSP70 can protect the auto-stability of cells and elevate the immune function in organism against tumor or multiple exogenous pathogens.Increasing of NF-κB expression presents in case of Helicobacter pylori（Hp） stimulation,it could induce inflammatory reaction,while inflammation factors could act inversely to enhance the expression of NF-κB,thus to cause and expand the damage of gastric mucosa.In addition,HSP shows blocking effect on the activation and expression of NF-κB.So,the author considered that in patients of Hp associated CGD-PEDH,HSP 70 exhibits the effect as that of ＂vital energy＂ and NF-κB play a role as the ＂evil qi＂ in Chinese medicine,the expressions of the two may embody the vital-evil combating manner of Pi-Wei damp-heat syndrome.