小剂量X射线照后TIL细胞体外扩增及抗癌作用的变化

Reaction of low does ionizing radiation on amplification in vitro and antitumor effect of TIL cells

目的:为了解小剂量射线对肿瘤浸润淋巴细胞体外扩增及抗癌细胞作用的影响。方法:从肝癌肿瘤模型小鼠腹水中分离取得肿瘤浸润淋巴细胞(TIL),给予不同剂量的X线照射,后培养,观察其对TIL细胞扩增及抗肿瘤活性的影响。结果:小剂量电离辐射可增加TIL细胞的扩增量,增加对肿瘤细胞的杀伤活性。结论:小剂量射线对肿瘤浸润淋巴细胞体外扩增及抗肿瘤均有显著作用。

OBJECTIVE：To study the the influence of low does ionizing radiation on amplification in vitro and antitumor effect of TIL cells.METHODS：Take TIL cells separated from the abdominal dropsy of liver cancer bearing mouse were taken.irradiate with different low-dose X-ray and culture TIL cells after irradiation.Its influence were observed on amplification and antitumor effects of TIL cells.RESULTS：Low-does ionizing radiation improved the amplification volume of TIL cell and enhances the lethality of tumor cells.CONCLUSION：Low-dose X-rays on can result in the amplification of TIL enhance the TILS cytotoxicity significantly.