胃癌组织VEGF-C表达与MSCT表现相关性的研究

Correlative study of MSCT features and expressions of VEGF-C in gastric carcinoma tissues

目的:探讨胃癌VEGF-C表达与MSCT表现的关系。方法:对48例胃癌患者术前1周行MSCT平扫及增强扫描,术后应用免疫组织化学染色法检测胃癌组织VEGF-C的表达。结果:CT图像显示的肿瘤强化幅度≥30HU组VEGF-C阳性表达率(91.3%)明显高于强化幅度<30HU组(52.0%),有浆膜侵犯组VEGF-C阳性表达率(87.1%)明显高于无浆膜侵犯组(41.2%),淋巴结转移组VEGF-C阳性表达率(81.6%)高于无淋巴结转移组(30.0%),P均<0.05。结论:胃癌组织VEGF-C表达与CT图像显示的胃癌强化幅度、浸润深度、淋巴结转移相关。

OBJECTIVE：To investigate the relationship between MSCT features and expressions of VEGF-C in advanced gastric carcinoma tissues.METHODS：Both plain CT scan and contrast-enhanced MSCT scan were performed in 48 patients with gastric cancer.All 48 patients underwent gastrectomy within one week after CT scanning.After operation,the specimens were used immunohistochemical staining to detect the expression of VEGF-C.RESULTS：The positive rates of VEGF-C were 91.3% and 52.0% in the contrast enhancement over and under 30 HU.The positive rates of VEGF-C were 87.1% and 41.2% in patients with and without serosal invasion respectively.The VEGF-C-positive rates were 81.6% and 30.0% in patients with and without lymph node metastasis.All the differences had statistical significance（P0.05）.CONCLUSION：The VEGF-C expression is closely correlated with the contrast enhancement,depth of invasion,lymph node metastasis.