摘要
肌动蛋白解聚因子/丝切蛋白家系(actin depolymerizing factor/cofilin,ADF/cofilin)作为一族肌动蛋白结合蛋白,广泛存在于真核细胞的细胞骨架中,该家族蛋白能够通过切断肌动蛋白丝并结合肌动蛋白单体上,从而增加肌动蛋白解聚作用在肌动蛋白动力中发挥重要作用。细胞内外信号分子以及自身磷酸化如LIM激酶和TES激酶,胰岛素等均可调节该家族蛋白与微丝结合,藉以完成多种细胞功能。围绕肌动蛋白解聚因子/丝切蛋白家族的系列研究特别是人类疾病与该家族作用机制的关系正日益成为研究热点,但该领域仍有许多问题尚不清楚,如该家族是怎样准确与肌动蛋白结合并发挥解聚作用的分子机械动力学细节等的研究。
The actin depolymerizing factor/cofilin （ADF/cofilins） are a family of actin-binding proteins expressed in all eukaryotic cells. The ADF/cofilins appear to have multiple functions, and this is reflected in their very complex association with both monomeric and filamentous actin. Phosphorylation by some kinases and other factors such as LIM kinases 1 and 2, TESK land TESK 2 kinase, Insulin, etc, prevents ADF/cofilins from binding actin. The serial researchs of ADF/cofilins are increasingly becoming study hot spots, especially on the relationship between homo-sapiens disease and mechanism of action of ADF/cofilins Now in this domain wilderness details are still far from clear, such as the mechanism by which actin filaments are depolymerized by ADF/cofilins has been controversial.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第50期9941-9945,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家自然科学基金资助项目(30600599)~~
