血管内皮细胞损伤与修复的机制研究(英文)

Vascular endothelial cell injury and repair mechanisms

血管内皮细胞不仅是循环血液与血管平滑肌细胞间的机械屏障,而且是人体最大、最重要的一种内分泌器官,但它很容易受到各种物理、化学因素的损伤;受损后其内分泌功能必然失调,使其分泌的多种活性物质或是与这些活性物质有关的其他物质之间的平衡被打破,从而导致心血管系统的功能障碍。文章对引起血管内皮细胞损伤的多种机制进行回顾,探讨血管内皮细胞的修复机制,进而研究如何保护和修复已损伤的血管内皮细胞,并改善血管疾病的预后。

The vascular endothelial cells （VECs） are not only a mechanical barrier of blood cycle cells and vascular smooth muscle cells, but also largest and most important type of endocrine organs. It is highly susceptible to a variety of physical and chemical factors in the injury; damaged VECs, especially the disordered endocrine function, the inevitable imbalance to a variety of active substances secreted or related active substances, finally result in dysfunction of cardiovascular system. This article reviews many mechanisms underlying VECs injury, investigates VECs repair mechanisms, and study ways to protect and repair the injured VECs, and improve the prognosis of vascular disease.