颅脑损伤后血液中S100β含量与损伤程度的关系

The correlation between the late level of serum S100β protein and the severity after traumatic brain injury

目的探讨血清中S100β蛋白含量与创伤性脑损伤程度的关系及法医学意义。方法选取健康体检者、颅脑损伤患者和其他创伤患者各30名作为研究对象,再根据入院时的GCS评分,将颅脑损伤患者分为轻中型组(GCS≥8分)和重型组(GCS<8分)。用ELISA法对上述研究对象血清中S100β蛋白含量进行检测。结果在脑外伤6h内,颅脑损伤组血清S100β蛋白含量较正常对照组和创伤对照组升高,差异有统计学意义(P<0.05);重型组与轻中型组相比,差异有统计学意义(P<0.05)。血清中S100β蛋白含量越高,患者颅脑损伤程度越严重。结论S100β蛋白可作为早期检测创伤性颅脑损伤的指标之一,其含量越高,颅脑损伤程度越重。

Objective To observe the expression of S100β protein in the traumatic brain injury and in- vestigate its relation to the severity of the TBI patients. Methods To collect 30 volunteer controls, 30 patients with traumatic brain injury and 30 patients with trauma expect traumatic brain injury, according Glasgow Coma Scale（GCS）, TBI patients were divided into tow groups, the minor group is GCS≥8, the severe group is GCS 〈 8. ELISA method was used for observing the expression of S100β protein in serum from the controls and patients. Results Within 6 hours after TBI, the concentration of S100β protein increased higher in patients of TBI than the others（P 〈0.05 ）. The concentration of S100β protein increased higher in the severe group（ GCS 〈 8 ） than the minor group （ P 〈 0.05 ）. The higher level of serum S100β protein, the more severe of TBI patients, the higher level of serum S100β protein. Conclusion The serums S100β protein can be a special index for the early diagnosis of TBI, the higher level of it, The more severe of patients.