c-jun在组织损伤中的表达变化及其法医学意义

Expression of c-jun in injured tissues and its forensic interest

c-jun原癌基因是即刻早期基因jun家族成员之一,属于碱性亮氨酸拉链家族核内转录因子成员,可以结合在许多基因的启动子上参与基因转录的调控,其表达产物在多种基因表达、细胞增殖、分化、凋亡等过程中起重要作用。本文就c-jun的结构、生物学功能、调控方式及其在组织损伤中的作用进行综述,旨在进一步对组织损伤程度和伤后时间推断的法医学研究提供参考资料。

Oncogene c-jun is a member of jun family, the immediately early genes（IEGs）, and belongs to one of the nuclear transcription factors of basic leucine zipper（bZIP） family. Combined with many gene promotors, c-jun is involved in the regulation of gene transcription. Its products play important roles in regulating gene expression, cell proliferation, differentiation and apoptosis. The structure, biological function, regulation of c-jun and its roles contributing to tissue damage are reviewed in this article, which may provide understanding for severity of tissue injury and wound age estimation in the field of forensic pathology.